Topical delivery of a Rho-kinase inhibitor to the cornea via mucoadhesive film.

Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension

In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow pathway actively regulate conventional outflow resistance was proposed in the 1990s and systematically pursued, exposing novel cellular and molecular mechanisms of intraocular pressure (IOP) regulation. The critical discovery that pharmacologic manipulation of the cytoskeleton of outflow pathway cells dec...

pH-Sensitive Mucoadhesive Film-Forming Gels and Wax-Film Composites Suitable for Topical and Mucosal Delivery of Molecules

Preparation of Diphenhydramine Hydrochloride Mucoadhesive Oral Film and the Evaluation of its Pharmaceutics characteristics

Background & Objective: In recent years, mucoadhesive drug delivery systems has shown interested for prolonging the residence time of the dosage form and for providing a controlled rate of drug release. Mucoadhesive buccal films can enhance drug bioavailability by absorption through buccal mucosa and bypassing the first pass metabolism for improved therapeutic effect.. In addition, buccal films...

Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 3(2) full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concent...

Preparation and pharmaceutical evaluation of Mucoadhesive Buccal film extracts of petroselinum for pharyngitis symptoms

Background: Recently, the mucosa has attracted attention due to its large arteries and high permeability for drug delivery. Due to the anti-inflammatory effect of parsley and easy access to this plant in Iran and the fact that the adhesive mucosa film is a new method with high performance and efficiency of drug transfer, this study was done to evaluate the effect of this plant on the pharyngiti...